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Creatine speeds up Rehabilitation after injury

Muscle disuse leads to muscle atrophy (decreased muscle volume), reduced muscle force, reduced muscle energy stores and reduced maximal power. The most prominent condition of muscle disuse is immobilization, for example when a broken leg or an arm is immobilized in a cast for some period of time, or if an athlete has to stop training and competing due to an injury

In contrast Creatine supplementation negated a decrease of Phosphocreatine and offsets the decline in muscle protein content during immobilization and led to a increase of 12% Phosphocreatine after the first 3 weeks of rehabilitation.

Peter Hespel et al. (2001) studied the effects of Creatine supplementation during muscle disuse and subsequent training in a double-blind placebo-controlled trial. The right leg of 22 healthy young volunteers was immobilized using a cast for 2 weeks after which the subjects participated in a 10-week rehabilitation program (heavy resistance training). During immobilization, muscle Phosphocreatine concentration decreased by 15% in the placebo group and returned to baseline within the first 3 weeks of rehabilitation.