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Classic toxicity data of Creapure
We havemuch of animal and human trials to prove the safety of
PreVent Creatine supplementation. Besides the classic toxicology,
PreVent/Creapure was tested in more than 50 clinical trials. People
of all ages (from several months up to age 70+) in sports and
non-sports applications, over periods of more than 21 months used
Creapure without any severe side effects. Due to different impurity
profiles of different Creatine manufactures, only Creapure has such
a proven safety profile.
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Acute Toxicity
1.1. Acute oral toxicityLD50 rat: >
2000 mg/kg
1.2. Acute intraperitoneal toxicity
LD50 mouse: > 2000 mg/kg
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Local Tolerance
2.1. Skin irritation rabbit: No skin
irritation
2.3. Sensitization guinea pig: not
sensitizing
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Mutagenicity Not mutagenic in
the Ames test
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Subactue Toxicity rat: repeated
dose (28 days) toxicity (oral) No treatment-related findings
noted, No Observed Adverse Effect Level (NOAEL) > 2000 mg/kg
bw/day
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Are there other forms of Creatine besides
Creatine Monohydrate?
Citrate (Creatine Citrate) and Puruvate (Creatine Pyruvate).
Are there quality differences in different
Creatine products?
Creatine products with more than 5% impurities have been found on
the market.
Inferior starting materials or reducing the amount of water during
"recrystallization" results in increased amounts of impurities (such
as Dicyandiamide (dimerization product of Cyanamide), Creatinine
(Cyclization product of Creatine) and Dihydrotriazines).
Worldwide authorities warn about potential health risks resulting
from present impurities in Dietary Supplements and in Creatine
Monohydrate products. Degussa’s Creapure has a very strict
specification on potential impurities in Creatine Monohydrate.
Зad creatine should not be consumed
together with coffee;
Try to avoid taking high amounts of Caffeine with Creatine.
Simultaneous supplementation of large amounts of Caffeine (e.g. 4
cups of coffee) eliminates the ergogenic effects of Creatine by
interfering with the resynthesis of Phosphocreatine. Lower amounts
of Caffeine (e.g. 1-2 cups of Coffee) seem not to influence the
efficacy of Creatine
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